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Diastereoselective synthesis of pyrrolidine derivatives via a one-pot nitro-Mannich/hydroamination cascade using base and gold catalysis.

Abstract:
An efficient one-pot nitro-Mannich/hydroamination cascade reaction for the synthesis of substituted pyrrolidines bearing three stereocentres is reported. Proceeding under the control of a combination of base and gold(I) catalysts, the cascade reaction affords the pyrrolidine products in high yields with good to excellent diastereoselectivities.
Publication status:
Published

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Publisher copy:
10.1039/c3cc40729b

Authors


Ďuriš, A More by this author
Barber, DM More by this author
Sanganee, HJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Chemical communications (Cambridge, England)
Volume:
49
Issue:
27
Pages:
2777-2779
Publication date:
2013-04-05
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
URN:
uuid:d60bd090-c1ab-4a75-bb5d-3acc21c15a57
Source identifiers:
387105
Local pid:
pubs:387105

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