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Ubiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1

Abstract:

BACKGROUND: Phosphorylation by the phospho-inositide-dependent kinase 1 (PDK1) is essential for many growth factor-activated kinases and thus plays a critical role in various processes such as cell proliferation and metabolism. However, the mechanisms that control PDK1 have not been fully explored and this is of great importance as interfering with PDK1 signaling may be useful to treat diseases, including cancer and diabetes. METHODOLOGY/PRINCIPAL FINDINGS: In human cells, few mono-ubiquitin...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
7
Issue:
2
Pages:
e31003
Publication date:
2012-02-07
Acceptance date:
2011-12-29
DOI:
EISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:d608ae00-5655-465f-aadc-ccd43a583e4d
Local pid:
pubs:489968
Source identifiers:
489968
Deposit date:
2014-11-20

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