IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma.
Background: High-grade osteosarcoma is an aggressive tumor most often developing in the long bones of adolescents, with a second peak in the 5th decade of life. Better knowledge on cellular signaling in this tumor may identify new possibilities for targeted treatment.
Methods: We performed gene set analysis on previously published genome-wide gene expression data of osteosarcoma cell lines (n=19) and pretreatment biopsies (n=84). We characterized ov...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Publisher's version
- Publisher copy:
- Copyright holder:
- Kuijjer et al.
- Copyright date:
- © 2013 Kuijjer et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.