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IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma.

Abstract:

Background: High-grade osteosarcoma is an aggressive tumor most often developing in the long bones of adolescents, with a second peak in the 5th decade of life. Better knowledge on cellular signaling in this tumor may identify new possibilities for targeted treatment.

Methods: We performed gene set analysis on previously published genome-wide gene expression data of osteosarcoma cell lines (n=19) and pretreatment biopsies (n=84). We characterized ov...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Files:
Publisher copy:
10.1186/1471-2407-13-245

Authors


Kuijjer, ML More by this author
Peterse, EF More by this author
van den Akker, BE More by this author
Briaire-de Bruijn, IH More by this author
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Publisher:
BioMed Central Ltd. Publisher's website
Journal:
BMC Cancer Journal website
Volume:
13
Issue:
1
Pages:
Article: 245
Publication date:
2013
DOI:
EISSN:
1471-2407
ISSN:
1471-2407
URN:
uuid:d5ed4190-670c-4e90-b1e0-33dd0718d717
Source identifiers:
411225
Local pid:
pubs:411225

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