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Combined fMRI-MRS acquires simultaneous glutamate and BOLD-fMRI signals in the human brain

Abstract:

Combined fMRI-MRS is a novel method to non-invasively investigate functional activation in the human brain using simultaneous acquisition of hemodynamic and neurochemical measures. The aim of the current study was to quantify neural activity using combined fMRI-MRS at 7 T. BOLD-fMRI and semi-LASER localization MRS data were acquired from the visual cortex of 13 participants during short blocks (64s) of flickering checkerboards. We demonstrate a correlation between glutamate and BOLD-fMRI time...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.neuroimage.2017.04.030

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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Author
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Department:
Oxford, MSD, Clinical Neurosciences
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Author
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Department:
Oxford, MSD, RDM
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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Department:
Oxford, MSD, Clinical Neurosciences
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Funding agency for:
Bridge, H
Royal Society More from this funder
Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Neuroimage Journal website
Volume:
155
Pages:
113–119
Publication date:
2017-04-18
Acceptance date:
2017-04-13
DOI:
EISSN:
1095-9572
ISSN:
1053-8119
Pubs id:
pubs:691102
URN:
uri:d5e5aa7c-6456-4771-8b59-b3392780400e
UUID:
uuid:d5e5aa7c-6456-4771-8b59-b3392780400e
Local pid:
pubs:691102

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