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Thesis

Germline determinants of 5-fluorouracil drug toxicity and patient survival in colorectal cancer

Abstract:

Despite a decade of publications investigating the effect of germline polymorphisms on both toxicity related to treatment with 5-fluorouracil-based (5-FU) chemotherapy and prognosis following diagnosis with colorectal cancer (CRC), few genetic biomarkers have been identified convincingly. For 5-FU toxicity and CRC prognosis, in four results chapters, this thesis aims to validate previously-reported genetic biomarkers, identify new markers, determine the mechanistic basis of associated poly...

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Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Research group:
Molecular and Population Genetics (MPG) Group
Oxford college:
Balliol College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
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Funding agency for:
Daniel Norris Rosmarin
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:d5e2c306-689c-4c53-b4c3-2c1001b04ec6
Local pid:
ora:8749

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