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Journal article

Replication error deficient and proficient colorectal cancer gene expression differences caused by 3'UTR polyT sequence deletions.

Abstract:

Replication error deficient (RER+) colorectal cancers are a distinct subset of colorectal cancers, characterized by inactivation of the DNA mismatch repair system. These cancers are typically pseudodiploid, accumulate mutations in repetitive sequences as a result of their mismatch repair deficiency, and have distinct pathologies. Regulatory sequences controlling all aspects of mRNA processing, especially including message stability, are found in the 3'UTR sequence of most genes. The relevant ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1015604107

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, Molecular Medicine
McGowan, S More by this author
Bodmer, WF More by this author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
107
Issue:
49
Pages:
21058-21063
Publication date:
2010-12-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:d5e0e951-179d-4752-bebf-f2c6f4a60e09
Source identifiers:
179140
Local pid:
pubs:179140

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