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Immunoregulatory function of IL-27 and TGF-β1 in cardiac allograft transplantation

Abstract:

Background: Deciphering the mechanisms of tolerance represents a crucial aim of research in transplantation. We previously identified by DNA chip interleukin (IL)-27 p28 and transforming growth factor (TGF)-β1 as overexpressed in a model of rat cardiac allograft tolerance mediated by regulatory CD4 +CD25 + T cells. The role of these two molecules on the control of the inflammatory response remains controversial. However, both are involved in the regulation of the T helper 17/Treg axis, sugges...

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Publisher copy:
10.1097/TP.0b013e31825b0c38

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Journal:
Transplantation More from this journal
Volume:
94
Issue:
3
Pages:
226-233
Publication date:
2012-08-15
DOI:
ISSN:
0041-1337
Language:
English
Keywords:
Pubs id:
pubs:348912
UUID:
uuid:d5dd3f08-ef9d-4c2c-845f-6b00a0e06acf
Local pid:
pubs:348912
Source identifiers:
348912
Deposit date:
2013-11-17

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