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Journal article

Allergens displayed on virus-like particles are highly immunogenic but fail to activate human mast cells.

Abstract:

Background

The goal of allergen-specific immunotherapy is the induction of protective immune responses in the absence of anaphylactic reactions. We have previously shown that Fel d 1, the major cat allergen, displayed in a repetitive fashion on virus-like particles (VLPs) may fulfill these criteria. Specifically, Fel d 1 on VLPs induced strongly increased protective IgG responses compared to free allergen in mice while anaphylactic reactions were essentially abolished. Here we ex...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1111/all.13268

Authors


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Swiss National Science Foundation More from this funder
Publisher:
Wiley Publisher's website
Journal:
Allergy Journal website
Volume:
73
Issue:
2
Pages:
341-349
Publication date:
2017-08-08
Acceptance date:
2017-08-03
DOI:
EISSN:
1398-9995
ISSN:
0105-4538
Pubs id:
pubs:723924
URN:
uri:d5c1c98e-3fb6-45e8-94f2-396549d4cc2a
UUID:
uuid:d5c1c98e-3fb6-45e8-94f2-396549d4cc2a
Local pid:
pubs:723924

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