Oxidative stress-induced dysregulation of arteriolar wall shear stress and blood pressure in hyperhomocysteinemia is prevented by chronic vitamin C treatment.

Journal article

We aimed to test the hypothesis that an enhanced level of reactive oxygen species (ROS) is primarily responsible for the impairment of nitric oxide (NO)-mediated regulation of arteriolar wall shear stress (WSS) in hyperhomocysteinemia (HHcy). Thus flow/WSS-induced dilations of pressurized gracilis muscle arterioles (basal diameter: approximately 170 microm) isolated from control (serum Hcy: 6 +/- 1 microM), methionine diet-induced HHcy rats (4 wk, serum Hcy: 30 +/- 6 microM), and HHcy rats tr...

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Authors: Bagi, Z; Cseko, C; Tóth, E; Koller, A

• Publication status: Published
• Journal: American journal of physiology. Heart and circulatory physiology
• Volume: 285
• Issue: 6
• Pages: H2277-H2283
• Publication date: 2003-12-01
• DOI: 10.1152/ajpheart.00448.2003
• EISSN: 1522-1539
• ISSN: 0363-6135
• Language: English
• Keywords: Oxidative Stress; Dinoprost; Ionophores; Blood Pressure; Calcimycin; Ascorbic Acid; Signal Transduction; F2-Isoprostanes; Penicillamine; Rats; Nitric Oxide Donors; Rats, Wistar; Muscle, Skeletal; Animals; Arterioles; Male; Stress, Mechanical; Antioxidants; Hyperhomocysteinemia; Vascular Resistance