Journal article
Oxidative stress-induced dysregulation of arteriolar wall shear stress and blood pressure in hyperhomocysteinemia is prevented by chronic vitamin C treatment.
- Abstract:
-
We aimed to test the hypothesis that an enhanced level of reactive oxygen species (ROS) is primarily responsible for the impairment of nitric oxide (NO)-mediated regulation of arteriolar wall shear stress (WSS) in hyperhomocysteinemia (HHcy). Thus flow/WSS-induced dilations of pressurized gracilis muscle arterioles (basal diameter: approximately 170 microm) isolated from control (serum Hcy: 6 +/- 1 microM), methionine diet-induced HHcy rats (4 wk, serum Hcy: 30 +/- 6 microM), and HHcy rats tr...
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- Publication status:
- Published
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- Publisher copy:
- 10.1152/ajpheart.00448.2003
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Authors
Bibliographic Details
- Journal:
- American journal of physiology. Heart and circulatory physiology
- Volume:
- 285
- Issue:
- 6
- Pages:
- H2277-H2283
- Publication date:
- 2003-12-05
- DOI:
- EISSN:
-
1522-1539
- ISSN:
-
0363-6135
- URN:
-
uuid:d5c08942-8b8b-49c7-9c1d-854ac50d468a
- Source identifiers:
-
164438
- Local pid:
- pubs:164438
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2003
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