- Abstract:
-
Prior studies demonstrated that NK cells isolated from adult peripheral blood kill the HLA-A-, HLA-B-, and HLA-C-deficient B lymphoblastoid cell line 721.221, but many are unable to kill 721.221 cells transfected with HLA-G, a molecule expressed preferentially on fetal cytotrophoblasts. To determine the biologic relevance of this recognition, we established NK cell clones from the placenta and demonstrate that these NK cells also were unable to kill 721.221 cells expressing HLA-G. Recognition...
Expand abstract - Publication status:
- Published
- Journal:
- Journal of immunology (Baltimore, Md. : 1950)
- Volume:
- 159
- Issue:
- 3
- Pages:
- 1072-1075
- Publication date:
- 1997-08-05
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- URN:
-
uuid:d5b9bfc9-febe-45dc-9aa6-b545739836ab
- Source identifiers:
-
475982
- Local pid:
- pubs:475982
- Language:
- English
- Keywords:
- Copyright date:
- 1997
Journal article
CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells.
Actions
Authors
Bibliographic Details
Item Description
Terms of use
Metrics
Altmetrics
Dimensions
If you are the owner of this record, you can report an update to it here: Report update to this record