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CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells.

Abstract:

Prior studies demonstrated that NK cells isolated from adult peripheral blood kill the HLA-A-, HLA-B-, and HLA-C-deficient B lymphoblastoid cell line 721.221, but many are unable to kill 721.221 cells transfected with HLA-G, a molecule expressed preferentially on fetal cytotrophoblasts. To determine the biologic relevance of this recognition, we established NK cell clones from the placenta and demonstrate that these NK cells also were unable to kill 721.221 cells expressing HLA-G. Recognition...

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Publication status:
Published

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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
159
Issue:
3
Pages:
1072-1075
Publication date:
1997-08-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:d5b9bfc9-febe-45dc-9aa6-b545739836ab
Source identifiers:
475982
Local pid:
pubs:475982

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