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Abolishment of the Tyr-15 inhibitory phosphorylation site on cdc2 reduces the radiation-induced G(2) delay, revealing a potential checkpoint in early mitosis.

Abstract:

cdc2 is inactivated before mitosis by phosphorylation at its inhibitory sites, Thr-14 and Tyr-15. Irradiation prevents HeLa cells from completing the G(2)-M transition, and they arrest in G(2). Whereas phosphorylation at both of these sites occurs during the G(2) arrest, the individual role of each site in the G(2) delay has not previously been investigated. We have shown that the radiation-induced G(2) delay is preserved in wild-type or cdc2-AY-transfected cells (which retain Tyr-15); this d...

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Publication status:
Published

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Authors


Fletcher, L More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Cancer research
Volume:
62
Issue:
1
Pages:
241-250
Publication date:
2002-01-05
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:d5b612f3-c0b9-4919-8d83-31f0c4d3fb1a
Source identifiers:
131297
Local pid:
pubs:131297

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