Journal article icon

Journal article

Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells.

Abstract:

Increasing evidence suggests that regulatory T cell (Treg) function is impaired in chronic inflammatory diseases such as rheumatoid arthritis (RA). Here we demonstrate that Tregs are unable to modulate the spontaneous production of TNF-α from RA synovial cells cultured from the diseased synovium site. Cytokine (IL-2, IL-6, TNF-α) activated T cells (Tck), cells we previously demonstrated to mimic the effector function of pathogenic RA synovial T cells, contained Tregs that survived and divided...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1073/pnas.1112722108

Authors


Beavis, PA More by this author
Gregory, B More by this author
Cribbs, AP More by this author
Kennedy, A More by this author
Expand authors...
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
108
Issue:
40
Pages:
16717-16722
Publication date:
2011-10-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:d5b38852-5d20-4b9c-81c7-aca5a468397a
Source identifiers:
223545
Local pid:
pubs:223545

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP