- Abstract:
-
Increasing evidence suggests that regulatory T cell (Treg) function is impaired in chronic inflammatory diseases such as rheumatoid arthritis (RA). Here we demonstrate that Tregs are unable to modulate the spontaneous production of TNF-α from RA synovial cells cultured from the diseased synovium site. Cytokine (IL-2, IL-6, TNF-α) activated T cells (Tck), cells we previously demonstrated to mimic the effector function of pathogenic RA synovial T cells, contained Tregs that survived and divided...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.1112722108
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 108
- Issue:
- 40
- Pages:
- 16717-16722
- Publication date:
- 2011-10-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:d5b38852-5d20-4b9c-81c7-aca5a468397a
- Source identifiers:
-
223545
- Local pid:
- pubs:223545
- Copyright date:
- 2011
Journal article
Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells.
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