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Thesis

Computational studies of signalling at the cell membrane

Abstract:

In order to associate with the cytoplasmic leaflet of the plasma membrane, many cytosolic signalling proteins possess a distinct lipid binding domain as part of their overall fold. Here, a multiscale simulation approach has been used to investigate three membrane-binding proteins involved in cellular processes such as growth and proliferation. The pleckstrin homology (PH) domain from the general receptor for phosphoinositides 1 (GRP1-PH) binds phosphatidylinositol (3,4,5)-trisphosphate (PI(3,...

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Institution:
University of Oxford
Research group:
Structural Bioinformatics and Computational Biochemistry Unit
Oxford college:
Merton College
Department:
Medical Sciences Division - Biochemistry

Contributors

Role:
Supervisor
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Funding agency for:
Craig Nicholas Lumb
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:d5b2db00-1050-4191-8eff-3521a4885a0c
Local pid:
ora:6685

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