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Prolyl hydroxylase domain enzyme 2 is the major player in regulating hypoxic responses in rheumatoid arthritis.

Abstract:

OBJECTIVE: Rheumatoid arthritis (RA) is characterized by hypoxia and the expression of hypoxia-inducible transcription factors (HIFs), which coordinate cellular responses to hypoxia. The objective of this study was to analyze the expression and regulation of prolyl hydroxylase domain (PHD) enzymes and factor-inhibiting HIF-1α (FIH-1), which regulate cellular HIF levels, and to study the roles of these enzymes in RA fibroblast-like synoviocytes (RA FLS). METHODS: The expression of PHD and FIH...

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Publication status:
Published

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Publisher copy:
10.1002/art.34479

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Arthritis and rheumatism
Volume:
64
Issue:
9
Pages:
2856-2867
Publication date:
2012-09-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:d5abbae0-e401-43e2-989a-99e05e15ee97
Source identifiers:
323032
Local pid:
pubs:323032

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