Evolution of human immunodeficiency virus type 1 in a patient with cross-reactive neutralizing activity in serum.

Journal article

Analysis of longitudinally obtained HIV-1 env sequences from an individual with reported cross-reactive neutralizing activity revealed that the majority of viral variants obtained from serum between 4 and 7 years after seroconversion were unable to persist in peripheral blood. Here we show that these viral variants were more sensitive to autologous serum neutralization, had shorter envelopes with fewer potential N-linked glycosylation sites, and showed lower replication kinetics than successf...

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Authors: van Gils, M; Edo-Matas, D; Bowles, E; Burger, J; Stewart-Jones, G

• Journal: Journal of virology
• Volume: 85
• Issue: 16
• Pages: 8443-8448
• Publication date: 2011-08-01
• DOI: 10.1128/jvi.05214-11
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English
• Keywords: Amino Acid Sequence; Genetic Variation; Humans; HIV Antibodies; Cross Reactions; HIV Infections; Antibodies, Neutralizing; Genes, env; Evolution, Molecular; HIV-1; env Gene Products, Human Immunodeficiency Virus; Molecular Sequence Data; Sequence Analysis, Protein