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Properties of the human muscle nicotinic receptor, and of the slow-channel myasthenic syndrome mutant epsilonL221F, inferred from maximum likelihood fits.

Abstract:

The mechanisms that underlie activation of nicotinic receptors are investigated using human recombinant receptors, both wild type and receptors that contain the slow channel myasthenic syndrome mutation, epsilonL221F. The method uses the program HJCFIT, which fits the rate constants in a specified mechanism directly to a sequence of observed open and shut times by maximising the likelihood of the sequence with exact correction for missed events. A mechanism with two different binding sites wa...

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Publication status:
Published

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Authors


Hatton, CJ More by this author
Shelley, C More by this author
Brydson, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Molecular Medicine
Colquhoun, D More by this author
Journal:
The Journal of physiology
Volume:
547
Issue:
Pt 3
Pages:
729-760
Publication date:
2003-03-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:d5a24e35-f2ed-4f14-a76a-ea7fdc0cd9b3
Source identifiers:
324391
Local pid:
pubs:324391

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