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Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA

Abstract:
Oligonucleotides containing internal triazole-3'-LNA linkages bind to complementary RNA with similar affinity and specificity to unmodified oligonucleotides, and significantly better than oligonucleotides containing triazole alone. In contrast LNA on the 5'-side of the triazole does not stabilise duplexes. Triazole-LNA confers great resistance towards enzymatic degradation relative to LNA alone.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1039/c7cc05159j

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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Department:
Oxford, MPLS, Chemistry
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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Funding agency for:
Kumar, P
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Grant:
BB/J001694/2 (extending the boundaries of nucleic acid chemistry)
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Chemical Communications Journal website
Volume:
53
Issue:
63
Pages:
8910-8913
Publication date:
2017-08-03
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
Pubs id:
pubs:712427
URN:
uri:d598a302-ac2e-4bde-a461-959acb40af86
UUID:
uuid:d598a302-ac2e-4bde-a461-959acb40af86
Local pid:
pubs:712427
Language:
English

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