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CDC4/FBXW7 and the 'just enough' model of tumourigenesis.

Abstract:

There is good evidence to show that cancer-causing mutations are not always simple gain- and loss-of-function changes. One example is the APC gene, where the combination of mutations produces a 'just-right' level of Wnt signalling. A recent article by Berger and colleagues posited a 'continuum model' in which increasing or decreasing gene expression of function was linearly associated with tumourigenesis. Berger also proposed an 'obligate haploinsufficiency' or 'fail-safe' model, whereby hete...

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Publication status:
Published

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Publisher copy:
10.1002/path.4004

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
Journal:
The Journal of pathology
Volume:
227
Issue:
2
Pages:
131-135
Publication date:
2012-06-05
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
URN:
uuid:d5869112-d103-4599-b2d2-eb1bc6820b99
Source identifiers:
254284
Local pid:
pubs:254284

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