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Journal article

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation.

Abstract:

AIMS/HYPOTHESIS: Defects in pancreatic beta cell turnover are implicated in the pathogenesis of type 2 diabetes by genetic markers for diabetes. Decreased beta cell neogenesis could contribute to diabetes. The longevity and turnover of human beta cells is unknown; in rodents <1 year old, a half-life of 30 days is estimated. Intracellular lipofuscin body (LB) accumulation is a hallmark of ageing in neurons. To estimate the lifespan of human beta cells, we measured beta cell LB accumulation ...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-009-1562-x

Authors


Hughes, SJ More by this author
Igoillo-Esteve, M More by this author
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Journal:
Diabetologia
Volume:
53
Issue:
2
Pages:
321-330
Publication date:
2010-02-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:d585850b-01e5-4a51-abb2-1225eeff614f
Source identifiers:
102240
Local pid:
pubs:102240

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