- Abstract:
-
AIMS/HYPOTHESIS: Defects in pancreatic beta cell turnover are implicated in the pathogenesis of type 2 diabetes by genetic markers for diabetes. Decreased beta cell neogenesis could contribute to diabetes. The longevity and turnover of human beta cells is unknown; in rodents <1 year old, a half-life of 30 days is estimated. Intracellular lipofuscin body (LB) accumulation is a hallmark of ageing in neurons. To estimate the lifespan of human beta cells, we measured beta cell LB accumulation ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/s00125-009-1562-x
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- Journal:
- Diabetologia
- Volume:
- 53
- Issue:
- 2
- Pages:
- 321-330
- Publication date:
- 2010-02-05
- DOI:
- EISSN:
-
1432-0428
- ISSN:
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0012-186X
- URN:
-
uuid:d585850b-01e5-4a51-abb2-1225eeff614f
- Source identifiers:
-
102240
- Local pid:
- pubs:102240
- Copyright date:
- 2010
Journal article
The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation.
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