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Journal article

CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms.

Abstract:

CD4(+)CD25(+) regulatory T (T(R)) cells can inhibit a variety of autoimmune and inflammatory diseases, but the precise mechanisms by which they suppress immune responses in vivo remain unresolved. Here, we have used Helicobacter hepaticus infection of T cell-reconstituted recombination-activating gene (RAG)(-/-) mice as a model to study the ability of CD4(+)CD25(+) T(R) cells to inhibit bacterially triggered intestinal inflammation. H. hepaticus infection elicited both T cell-mediated and T c...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20021345

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of experimental medicine More from this journal
Volume:
197
Issue:
1
Pages:
111-119
Publication date:
2003-01-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Language:
English
Keywords:
Pubs id:
pubs:16187
UUID:
uuid:d58210df-30b4-4324-a8bb-18f95c84c484
Local pid:
pubs:16187
Source identifiers:
16187
Deposit date:
2012-12-19

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