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Journal article

Vandetanib inhibits growth of adenoid cystic carcinoma in an orthotopic nude mouse model.

Abstract:

PURPOSE: Adenoid cystic carcinoma (ACC) can often be controlled with surgery and postoperative adjuvant radiotherapy but is also characterized by late local recurrence and distant metastasis. No effective systemic therapeutic agents have been found to alter the natural history of ACC. Therefore, new therapeutic approaches are needed. In this study, we evaluated whether vandetanib (Zactima), a potent inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) and epidermal growth fac...

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Publication status:
Published

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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
14
Issue:
16
Pages:
5081-5089
Publication date:
2008-08-05
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
URN:
uuid:d577e97b-f593-4af3-b009-d1380411574a
Source identifiers:
312624
Local pid:
pubs:312624

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