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Molecular MRI enables early and sensitive detection of brain metastases.

Abstract:

Metastasis to the brain is a leading cause of cancer mortality. The current diagnostic method of gadolinium-enhanced MRI is sensitive only to larger tumors, when therapeutic options are limited. Earlier detection of brain metastases is critical for improved treatment. We have developed a targeted MRI contrast agent based on microparticles of iron oxide that enables imaging of endothelial vascular cell adhesion molecule-1 (VCAM-1). Our objectives here were to determine whether VCAM-1 is up-reg...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1073/pnas.1117412109

Authors


Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
109
Issue:
17
Pages:
6674-6679
Publication date:
2012-03-26
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Pubs id:
pubs:320448
UUID:
uuid:d5614cca-57ab-4a7a-b8c9-092f2419949f
Local pid:
pubs:320448
Source identifiers:
320448
Deposit date:
2012-12-19

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