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Structural modeling of heteromeric protein complexes from disassembly pathways and ion mobility-mass spectrometry.

Abstract:

Structure determination of macromolecular protein assemblies remains a challenge for well-established methods. Here, we provide an assessment of an emerging structural technique, ion mobility-mass spectrometry (IM-MS), and examine the use of collision cross-sections (CCSs), derived from IM-MS, as restraints for structure characterization of heteromeric protein assemblies. Using 15 complexes selected from the Protein Data Bank, we validate the use of low-resolution models by comparing their CC...

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Publication status:
Published

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Publisher copy:
10.1016/j.str.2012.07.001

Authors


Politis, A More by this author
Robinson, CV More by this author
Journal:
Structure (London, England : 1993)
Volume:
20
Issue:
9
Pages:
1596-1609
Publication date:
2012-09-05
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:d54b6844-c729-4206-8d2d-1653153ebdd3
Source identifiers:
350832
Local pid:
pubs:350832

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