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Contrasting metabolic effects of continuous and pulsatile growth hormone administration in young adults with type 1 (insulin-dependent) diabetes mellitus.

Abstract:

Plasma growth hormone profiles in adolescents with Type 1 (insulin-dependent) diabetes mellitus are characterized by both increases in pulse amplitude and higher baseline concentrations. To determine which of these abnormalities adversely affect metabolic control, we studied six young adults overnight on three occasions. On each night somatostatin (50-100 micrograms.m2-1.h-1) and glucagon (1 ng.kg-1.min-1) were infused continuously and 18 mU/kg of growth hormone was given as either: three dis...

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Publication status:
Published

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Publisher copy:
10.1007/bf00400482

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Journal:
Diabetologia
Volume:
35
Issue:
6
Pages:
542-549
Publication date:
1992-06-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:d53b1d9d-2193-49f7-9709-b3b017e2faa5
Source identifiers:
72758
Local pid:
pubs:72758

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