Journal article
The structural basis of the inhibition of human alpha-mannosidases by azafuranose analogues of mannose.
- Abstract:
-
Eight pyrrolidine, five pyrrolizidine and one indolizidine analogue(s) of the known alpha-mannosidase inhibitor, the azafuranose, 1,4-dideoxy-1,4-imino-D-mannitol (DIM), have been tested for inhibition of the multiple forms of alpha-mannosidase in human liver in vitro. Substitution of the ring nitrogen markedly decreased or abolished inhibition, but loss of the C-6 hydroxy group, as in 6-deoxy-DIM and 6-deoxy-6-fluoro-DIM, enhanced inhibition, particularly of the lysosomal alpha-mannosidase. ...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Biochemical journal
- Volume:
- 290 ( Pt 3)
- Pages:
- 743-749
- Publication date:
- 1993-03-01
- EISSN:
-
1470-8728
- ISSN:
-
0264-6021
- Source identifiers:
-
44120
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:44120
- UUID:
-
uuid:d533e1cd-bdf7-47ec-927c-e52f4635030a
- Local pid:
- pubs:44120
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1993
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