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The structural basis of the inhibition of human alpha-mannosidases by azafuranose analogues of mannose.

Abstract:

Eight pyrrolidine, five pyrrolizidine and one indolizidine analogue(s) of the known alpha-mannosidase inhibitor, the azafuranose, 1,4-dideoxy-1,4-imino-D-mannitol (DIM), have been tested for inhibition of the multiple forms of alpha-mannosidase in human liver in vitro. Substitution of the ring nitrogen markedly decreased or abolished inhibition, but loss of the C-6 hydroxy group, as in 6-deoxy-DIM and 6-deoxy-6-fluoro-DIM, enhanced inhibition, particularly of the lysosomal alpha-mannosidase. ...

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Publication status:
Published

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Journal:
The Biochemical journal
Volume:
290 ( Pt 3)
Pages:
743-749
Publication date:
1993-03-05
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:d533e1cd-bdf7-47ec-927c-e52f4635030a
Source identifiers:
44120
Local pid:
pubs:44120

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