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A physical map of 4 million bp around the Duchenne muscular dystrophy gene on the human X-chromosome.

Abstract:

Employing pulsed field gradient electrophoresis, we constructed a 4.5 million bp (Mb) Sfil restriction map of the human X-chromosomal region p21, harboring genes for Duchenne (DMD) and Becker Muscular Dystrophy. In a DMD patient with additional chronic granulomatosis and retinitis pigmentosa, the proximal 3.5 Mb is deleted. Another DMD patient, with additional glycerol kinase deficiency and adrenal hypoplasia, lacks at least 3.3 Mb in the middle region, including marker C7 but not B24, placin...

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Publication status:
Published

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Authors


van Ommen, GJ More by this author
Verkerk, JM More by this author
Hofker, MH More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Kunkel, LM More by this author
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Journal:
Cell
Volume:
47
Issue:
4
Pages:
499-504
Publication date:
1986-11-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:d5334a5f-31c7-4730-94d6-fbe7cc23d529
Source identifiers:
115666
Local pid:
pubs:115666

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