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A physical map of 4 million bp around the Duchenne muscular dystrophy gene on the human X-chromosome.

Abstract:

Employing pulsed field gradient electrophoresis, we constructed a 4.5 million bp (Mb) Sfil restriction map of the human X-chromosomal region p21, harboring genes for Duchenne (DMD) and Becker Muscular Dystrophy. In a DMD patient with additional chronic granulomatosis and retinitis pigmentosa, the proximal 3.5 Mb is deleted. Another DMD patient, with additional glycerol kinase deficiency and adrenal hypoplasia, lacks at least 3.3 Mb in the middle region, including marker C7 but not B24, placin...

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Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Cell More from this journal
Volume:
47
Issue:
4
Pages:
499-504
Publication date:
1986-11-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Language:
English
Keywords:
Pubs id:
pubs:115666
UUID:
uuid:d5334a5f-31c7-4730-94d6-fbe7cc23d529
Local pid:
pubs:115666
Source identifiers:
115666
Deposit date:
2012-12-19

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