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Experimental allergic encephalomyelitis (EAE) in mice selectively bred to produce high affinity (HA) or low affinity (LA) antibody responses.

Abstract:

Induction of experimental allergic encephalomyelitis (EAE) in mice genetically selected to produce either high affinity (HA) or low affinity (LA) antibody responses has revealed significant differences in disease susceptibility between the two lines. HA mice were highly susceptible to EAE following subcutaneous sensitization to mouse central nervous system (CNS) tissue emulsified in Freund's complete adjuvant (FCA). Furthermore, of HA mice surviving acute EAE, up to 93% subsequently developed...

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Publication status:
Published

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Authors


Bleasdale-Barr, KM More by this author
Holland, GP More by this author
Dal Canto, MC More by this author
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Journal:
Immunology
Volume:
69
Issue:
4
Pages:
519-524
Publication date:
1990-04-05
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:d51eae62-f2ae-44cd-bda2-ba654beaa707
Source identifiers:
110489
Local pid:
pubs:110489

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