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Rapid, B1-insensitive, dual-band quasi-adiabatic saturation transfer with optimal control for complete quantification of myocardial ATP flux

Abstract:

Purpose: Phosphorus saturation-transfer experiments can quantify metabolic fluxes non-invasively. Typically, the forward flux through the creatine-kinase reaction is investigated by observing the decrease in phosphocreatine (PCr) after saturation of γ-ATP. The quantification of total ATP utilisation is currently under-explored, as it requires simultaneous saturation of inorganic phosphate (Pi) and PCr. This is challenging, as currently available saturation pulses reduce th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/mrm.28647

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
ORCID:
0000-0002-6258-1299
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
ORCID:
0000-0003-2567-3642
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Publisher:
Wiley
Journal:
Magnetic Resonance in Medicine More from this journal
Volume:
85
Issue:
6
Pages:
2978-2991
Publication date:
2021-02-03
Acceptance date:
2020-11-24
DOI:
EISSN:
1522-2594
ISSN:
0740-3194
Language:
English
Keywords:
Pubs id:
1128988
Local pid:
pubs:1128988
Deposit date:
2020-11-25

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