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Single cell RNA-seq reveals profound transcriptional similarity between Barrett’s oesophagus and oesophageal submucosal glands

Abstract:

Barrett’s oesophagus is a precursor of oesophageal adenocarcinoma. In this common condition, squamous epithelium in the oesophagus is replaced by columnar epithelium in response to acid reflux. Barrett’s oesophagus is highly heterogeneous and its relationships to normal tissues are unclear. Here we investigate the cellular complexity of Barrett’s oesophagus and the upper gastrointestinal tract using RNA-sequencing of single cells from multiple biopsies from six patients with Barrett’s oesopha...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-018-06796-9

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Oxford Ludwig Institute
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Oxford Ludwig Institute
Severson, DT More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
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More from this funder
Funding agency for:
White, MJ
Ludwig Institute for Cancer Research More from this funder
NIHR Biomedical Research Centre More from this funder
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Pages:
Article: 4261
Publication date:
2018-10-15
Acceptance date:
2018-09-19
DOI:
ISSN:
2041-1723
Pubs id:
pubs:920617
URN:
uri:d513ad70-2e62-496c-8413-6a587f8f15d6
UUID:
uuid:d513ad70-2e62-496c-8413-6a587f8f15d6
Local pid:
pubs:920617

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