Journal article icon

Journal article

Single cell RNA-seq reveals profound transcriptional similarity between Barrett’s oesophagus and oesophageal submucosal glands

Abstract:

Barrett’s oesophagus is a precursor of oesophageal adenocarcinoma. In this common condition, squamous epithelium in the oesophagus is replaced by columnar epithelium in response to acid reflux. Barrett’s oesophagus is highly heterogeneous and its relationships to normal tissues are unclear. Here we investigate the cellular complexity of Barrett’s oesophagus and the upper gastrointestinal tract using RNA-sequencing of single cells from multiple biopsies from six patients with Barrett’s oesopha...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s41467-018-06796-9

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Role:
Author
More from this funder
Name:
Cancer Research UK
Funding agency for:
White, M
Grant:
C5255/A19498
More from this funder
Name:
Oxford University Clinical Academic Graduate School
Funding agency for:
Owen, R
More from this funder
Name:
Oxford Health Services Research Committee
Funding agency for:
Owen, R
More from this funder
Name:
Cancer Research UK
Grant:
Accelerator Award (C328/A21998)
More from this funder
Name:
NIHR Biomedical Research Centre
Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
9
Article number:
4261
Publication date:
2018-10-15
Acceptance date:
2018-09-19
DOI:
ISSN:
2041-1723
Pubs id:
pubs:920617
UUID:
uuid:d513ad70-2e62-496c-8413-6a587f8f15d6
Local pid:
pubs:920617
Source identifiers:
920617
Deposit date:
2018-09-20

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP