Journal article icon

Journal article

Allelic dimorphism of the erythocyte binding antigen-175 (eba-175) gene of Plasmodium falciparum and severe malaria: Significant association of the C-fragment with fatal outcome in Ghanaian children

Abstract:

Background: The erythrocyte binding antigen-175 (EBA-175) on Plasmodium falciparum merozoites mediates sialic acid dependent binding to glycophorin A on host erythrocytes and, therefore, plays a crucial role in cell invasion. Dimorphic allele segments have been found in its encoding gene with a 342 bp segment present in FCR-3 strains (F segment) and a 423 bp segment in CAMP strains (C-segment). Possible associations of the dimorphism with severe malaria have been analysed in a case-control st...

Expand abstract

Actions


Access Document


Publisher copy:
10.1186/1475-2875-3-1

Authors


Cramer, JP More by this author
Mockenhaupt, FP More by this author
Dittrich, S More by this author
Expand authors...
Journal:
Malaria Journal
Volume:
3
Pages:
1-20
Publication date:
2004-05-12
DOI:
ISSN:
1475-2875
URN:
uuid:d511a9d8-9d2e-4325-9772-dfc18873e1f7
Source identifiers:
458992
Local pid:
pubs:458992
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP