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Genome-wide association study identifies multiple loci influencing human serum metabolite levels

Abstract:

Nuclear magnetic resonance assays allow for measurement of a wide range of metabolic phenotypes. We report here the results of a GWAS on 8,330 Finnish individuals genotyped and imputed at 7.7 million SNPs for a range of 216 serum metabolic phenotypes assessed by NMR of serum samples. We identified significant associations (P < 2.31 - 10 g-10) at 31 loci, including 11 for which there have not been previous reports of associations to a metabolic trait or disorder. Analyses of Finnish twin pa...

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Publisher copy:
10.1038/ng.1073

Authors


Kettunen, J More by this author
Tukiainen, T More by this author
Sarin, A-P More by this author
Ortega-Alonso, A More by this author
Tikkanen, E More by this author
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Journal:
Nature Genetics
Volume:
44
Issue:
3
Pages:
269-276
Publication date:
2012-03-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:d4ff5bfd-6283-432f-9969-26ce74fb11e0
Source identifiers:
320782
Local pid:
pubs:320782
Language:
English

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