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Journal article

Toenail selenium status and DNA repair capacity among female BRCA1 mutation carriers.

Abstract:

Selenium is an important cofactor of various antioxidant enzymes and has been shown to enhance DNA repair in normal human fibroblasts. Oral selenium supplementation has also been shown to decrease the number of chromosome breaks in BRCA1 mutation carriers. Because the predisposition to cancer among BRCA1 mutation carriers may be linked to high rates of DNA damage and chromosome breakage, we evaluated the association between toenail selenium concentrations and three measures of DNA repair capa...

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Publication status:
Published

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Publisher copy:
10.1007/s10552-009-9495-8

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Journal:
Cancer causes and control : CCC
Volume:
21
Issue:
5
Pages:
679-687
Publication date:
2010-05-05
DOI:
EISSN:
1573-7225
ISSN:
0957-5243
URN:
uuid:d4f2ecbf-8d0f-4646-8311-6b847f409568
Source identifiers:
79246
Local pid:
pubs:79246

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