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Dissection of agonistic and blocking effects of CD200 receptor antibodies

Abstract:

The CD200 receptor (CD200R) is present mainly on myeloid cells and gives inhibitory signals when engaged by its ligand CD200. The interaction is currently of therapeutic interest in cancer and inflammation. However functional effects are complicated by the fact that CD200R is itself polymorphic and also a member of a paired receptor family with four closely related gene products in mice called CD200RLa etc. We show that a second allele of CD200R (termed CD200R(2)) that differs in 7 amino acid...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
8
Issue:
5
Pages:
e63325
Publication date:
2013-05-14
Acceptance date:
2013-03-31
DOI:
EISSN:
1932-6203
Language:
English
Keywords:
Pubs id:
pubs:402079
UUID:
uuid:d4e4ea02-58f6-4158-8626-d628ffe1a84b
Local pid:
pubs:402079
Source identifiers:
402079
Deposit date:
2013-11-16

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