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Variation within MBP gene predicts disease course in multiple sclerosis

Abstract:
Objective Prognosis following a first demyelinating event is difficult to predict, with no genetic markers of MS progression currently identified. Myelin basic protein (MBP) is a major component of the myelin sheath of CNS neurons and may play a central role in demyelinating diseases such as MS. However, genetic variation in MBP has not been implicated in MS onset risk in large genome‐wide association studies. We hypothesized that genetic variations in MBP may be a determinan... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1002/brb3.670

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ORCID:
0000-0003-1962-2574
More by this author
ORCID:
0000-0001-6521-3056
Charlesworth, JC More by this author
Van Der Mei, I More by this author
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Publisher:
Wiley Publisher's website
Journal:
Brain and Behavior Journal website
Volume:
7
Issue:
4
Pages:
Article: e00670
Publication date:
2017-03-09
Acceptance date:
2017-01-29
DOI:
EISSN:
2157-9032
ISSN:
2162-3279
Pubs id:
pubs:859337
URN:
uri:d4d50d04-a20a-4cf1-8ef0-f2c5fb38de2d
UUID:
uuid:d4d50d04-a20a-4cf1-8ef0-f2c5fb38de2d
Local pid:
pubs:859337

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