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Journal article

Regulatory T cells promote apelin-mediated sprouting angiogenesis in type 2 diabetes

Abstract:

The role of CD4+ T cells in the ischemic tissues of T2D patients remains unclear. Here, we report that T2D patients' vascular density was negatively correlated with the number of infiltrating CD4+ T cells after ischemic injury. Th1 was the predominant subset, and Th1-derived IFN-γ and TNF-α directly impaired human angiogenesis. We then blocked CD4+ T cell infiltration into the ischemic tissues of both Leprdb/db and diet-induced obese T2D mice. Genome-wide RNA sequencing shows an increased pro...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.celrep.2018.07.019

Authors


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Lui Chi Woo Institute of Innovative Medicine More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
24
Issue:
6
Pages:
1610-1626
Publication date:
2018-08-07
Acceptance date:
2018-07-05
DOI:
ISSN:
2211-1247
Pubs id:
pubs:897017
URN:
uri:d4ceb829-1241-44da-96f0-9d18a86807d2
UUID:
uuid:d4ceb829-1241-44da-96f0-9d18a86807d2
Local pid:
pubs:897017

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