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Genomic surveillance of 4CMenB vaccine antigenic variants among disease-causing Neisseria meningitidis isolates, United Kingdom, 2010–2016

Abstract:

In September 2015, 4CMenB meningococcal vaccine was introduced into the United Kingdom infant immunization program without phase 3 trial information. Understanding the effect of this program requires enhanced surveillance of invasive meningococcal disease (IMD) Neisseria meningitidis isolates and comparison with prevaccination isolates. Bexsero Antigen Sequence Types (BASTs) were used to analyze whole-genome sequences of 3,073 prevaccine IMD N. meningitidis isolates obtained during 2010−2016....

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3201/eid2404.171480

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Role:
Author
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Name:
Wellcome Trust
Grant:
087622
Publisher:
Centers for Disease Control and Prevention
Journal:
Emerging Infectious Diseases More from this journal
Volume:
24
Issue:
4
Publication date:
2018-03-01
Acceptance date:
2018-01-12
DOI:
EISSN:
1080-6059
ISSN:
1080-6040
Pubs id:
pubs:824042
UUID:
uuid:d4cd96e3-8459-4564-ae05-1c8b6c658716
Local pid:
pubs:824042
Source identifiers:
824042
Deposit date:
2018-03-21

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