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Journal article

Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models.

Abstract:

PURPOSE: The purpose of this study was to examine the antitumor effects of the novel vascular targeting agent ZD6126 and to use histology, CD31 immunohistochemistry, and electron microscopy to gain an insight into the mechanism of action of this novel agent. EXPERIMENTAL DESIGN: The antitumor effects of ZD6126 were examined using a range of solid tumor models: (a) ras-transformed mouse 3T3 fibroblasts (Hras5); and (b) human lung (Calu-6), colorectal (LoVo and HT-29), prostate (PC-3), ovarian...

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Publication status:
Published

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Authors


Blakey, DC More by this author
Westwood, FR More by this author
Hughes, GD More by this author
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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
8
Issue:
6
Pages:
1974-1983
Publication date:
2002-06-05
ISSN:
1078-0432
URN:
uuid:d4c87ffc-83f8-4932-8d6e-7acc29d230ee
Source identifiers:
131675
Local pid:
pubs:131675

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