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Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties

Abstract:

CD8(+) T lymphocytes play a key role in host defense, in particular against important persistent viruses, although the critical functional properties of such cells in tissue are not fully defined. We have previously observed that CD8(+) T cells specific for tissue-localized viruses such as hepatitis C virus express high levels of the C-type lectin CD161. To explore the significance of this, we examined CD8(+)CD161(+) T cells in healthy donors and those with hepatitis C virus and defined a pop...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.0914839107

Authors


Billerbeck, E More by this author
Lockstone, H More by this author
Grafmueller, S More by this author
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Wellcome Trust More from this funder
Medical Research Council More from this funder
James Martin School of the 21st Century More from this funder
Deutsche Forschungsgemeinschaft More from this funder
National Institute for Health Research More from this funder
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
107
Issue:
7
Pages:
3006-3011
Publication date:
2010-01-28
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:d4bfa42e-8bbb-4559-863c-0ecdc5ca1754
Source identifiers:
48473
Local pid:
pubs:48473

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