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Journal article

Adaptation of HIV-1 to human leukocyte antigen class I.

Abstract:

The rapid and extensive spread of the human immunodeficiency virus (HIV) epidemic provides a rare opportunity to witness host-pathogen co-evolution involving humans. A focal point is the interaction between genes encoding human leukocyte antigen (HLA) and those encoding HIV proteins. HLA molecules present fragments (epitopes) of HIV proteins on the surface of infected cells to enable immune recognition and killing by CD8(+) T cells; particular HLA molecules, such as HLA-B*57, HLA-B*27 and HLA...

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Publication status:
Published

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Publisher copy:
10.1038/nature07746

Authors


Kawashima, Y More by this author
Pfafferott, K More by this author
Matthews, P More by this author
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Journal:
Nature
Volume:
458
Issue:
7238
Pages:
641-645
Publication date:
2009-04-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:d4bcb072-5d5d-4465-9d90-7ff425a7bde1
Source identifiers:
21244
Local pid:
pubs:21244

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