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C-myc and the yeast transcription factor PHO4 share a common CACGTG-binding motif.

Abstract:

The basic-helix-loop-helix (b-HLH) motif is common to a number of proteins involved in transcriptional regulation and cell-type determination. The b-HLH motif is also present in the S. cerevisiae transcription factor PHO4 which positively regulates the acid phosphatase gene PHO5. In this report we show that the b-HLH region of PHO4 is sufficient to confer specific DNA-binding to the sequence CACGTG and, by comparison of the basic regions of PHO4 with those of other recently isolated CACGTG-bi...

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Publication status:
Published

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Authors


Jayaraman, PS More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
Journal:
Oncogene
Volume:
6
Issue:
7
Pages:
1099-1104
Publication date:
1991-07-05
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:d4a2d588-70e3-43e7-b888-bf75ecb32941
Source identifiers:
92935
Local pid:
pubs:92935

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