C-myc and the yeast transcription factor PHO4 share a common CACGTG-binding motif.

Journal article

The basic-helix-loop-helix (b-HLH) motif is common to a number of proteins involved in transcriptional regulation and cell-type determination. The b-HLH motif is also present in the S. cerevisiae transcription factor PHO4 which positively regulates the acid phosphatase gene PHO5. In this report we show that the b-HLH region of PHO4 is sufficient to confer specific DNA-binding to the sequence CACGTG and, by comparison of the basic regions of PHO4 with those of other recently isolated CACGTG-bi...

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Authors: Fisher, F; Jayaraman, P; Goding, C

• Publication status: Published
• Journal: Oncogene
• Volume: 6
• Issue: 7
• Pages: 1099-1104
• Publication date: 1991-07-01
• EISSN: 1476-5594
• ISSN: 0950-9232
• Language: English
• Keywords: Base Sequence; Nucleic Acid Conformation; Transcription Factors; Proto-Oncogene Proteins c-myc; Fungal Proteins; Transcription, Genetic; DNA; Saccharomyces cerevisiae Proteins; Binding Sites; Amino Acid Sequence; DNA-Binding Proteins; Saccharomyces cerevisiae; Sequence Homology, Nucleic Acid; Deoxyribonuclease I; Molecular Sequence Data