- Abstract:
-
[reaction: see text] Stereoselective aminohydroxylation and dihydroxylation using osmium(VIII) oxidants enabled the short and efficient synthesis of the aminocyclitol core of hygromycin A. In addition to allowing the selective introduction of the heteroatoms N and O, the use of osmium (via an osmate ester) as a protecting group for a 1,2-glycol is also reported. This tactic allowed efficient differentiation of otherwise equivalent hydroxyl groups and allowed us to complete the synthesis in sh...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1021/ol0473750
-
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- Journal:
- Organic letters
- Volume:
- 7
- Issue:
- 7
- Pages:
- 1275-1277
- Publication date:
- 2005-03-05
- DOI:
- EISSN:
-
1523-7052
- ISSN:
-
1523-7060
- URN:
-
uuid:d49db24d-b926-42aa-919f-3d283ce200c7
- Source identifiers:
-
33038
- Local pid:
- pubs:33038
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
Concise and enantioselective synthesis of the aminocyclitol core of hygromycin A.
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