Journal article icon

Journal article

Concise and enantioselective synthesis of the aminocyclitol core of hygromycin A.

Abstract:

[reaction: see text] Stereoselective aminohydroxylation and dihydroxylation using osmium(VIII) oxidants enabled the short and efficient synthesis of the aminocyclitol core of hygromycin A. In addition to allowing the selective introduction of the heteroatoms N and O, the use of osmium (via an osmate ester) as a protecting group for a 1,2-glycol is also reported. This tactic allowed efficient differentiation of otherwise equivalent hydroxyl groups and allowed us to complete the synthesis in sh...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1021/ol0473750

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Organic letters
Volume:
7
Issue:
7
Pages:
1275-1277
Publication date:
2005-03-05
DOI:
EISSN:
1523-7052
ISSN:
1523-7060
URN:
uuid:d49db24d-b926-42aa-919f-3d283ce200c7
Source identifiers:
33038
Local pid:
pubs:33038

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP