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Failure of 3,4-diaminopyridine and edrophonium to produce significant clinical benefit in neurotoxicity following the bite of Papuan taipan (Oxyuranus scutellatus canni).

Abstract:

Progressive systemic neurotoxicity is a common feature in patients envenomed following the bite of a Papuan taipan (Oxyuranus scutellatus canni). Respiratory paralysis, which commonly results, accounts for considerable morbidity and mortality. Established neurotoxicity does not respond to antivenom. In this study, a combination of clinical and electrophysiological variables was used to assess the effect of edrophonium and 3,4-diaminopyridine in patients with significant neurotoxicity. Both dr...

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Publication status:
Published

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Authors


Trevett, AJ More by this author
Lalloo, DG More by this author
Nwokolo, NC More by this author
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Journal:
Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume:
89
Issue:
4
Pages:
444-446
Publication date:
1995
DOI:
EISSN:
1878-3503
ISSN:
0035-9203
URN:
uuid:d49b735f-4e92-4d7f-9c20-00e2501900af
Source identifiers:
61150
Local pid:
pubs:61150

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