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Journal article

HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis

Abstract:

The repression of telomerase activity during cellular differentiation promotes replicative aging and functions as a physiological barrier for tumorigenesis in long-lived mammals, including humans. However, the underlying mechanisms remain largely unclear. Here we describe how miR-615-3p represses hTERT expression. mir-615-3p is located in an intron of the HOXC5 gene, a member of the highly conserved homeobox family of transcription factors controlling embryogenesis and development. Unexpected...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-017-02601-1

Authors


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Role:
Author
ORCID:
0000-0003-2977-0087
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Role:
Author
ORCID:
0000-0003-3077-1968
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Name:
NRF
Funding agency for:
Li, S
Grant:
NRF2016NRF-CRP001-024
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Name:
Medical Research Council
Grant:
MC_UU_12009/15
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Name:
MOE
Grant:
MOE2014-T2-1-138
Publisher:
Nature Publishing Group
Journal:
Nature Communications More from this journal
Volume:
9
Article number:
100
Publication date:
2018-01-08
Acceptance date:
2017-12-13
DOI:
ISSN:
2041-1723
Pmid:
29311615
Language:
English
Pubs id:
pubs:817446
UUID:
uuid:d490cf3d-3f56-4839-aaf0-e8f4167c0f8a
Local pid:
pubs:817446
Source identifiers:
817446
Deposit date:
2018-05-11

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