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HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis

Abstract:

The repression of telomerase activity during cellular differentiation promotes replicative aging and functions as a physiological barrier for tumorigenesis in long-lived mammals, including humans. However, the underlying mechanisms remain largely unclear. Here we describe how miR-615-3p represses hTERT expression. mir-615-3p is located in an intron of the HOXC5 gene, a member of the highly conserved homeobox family of transcription factors controlling embryogenesis and development. Unexpected...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-017-02601-1

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ORCID:
0000-0003-2977-0087
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ORCID:
0000-0003-3077-1968
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Funding agency for:
Li, S
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Grant:
MOE2014-T2-1-138
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Pages:
Article: 100
Publication date:
2018-01-08
Acceptance date:
2017-12-13
DOI:
ISSN:
2041-1723
Pubs id:
pubs:817446
URN:
uri:d490cf3d-3f56-4839-aaf0-e8f4167c0f8a
UUID:
uuid:d490cf3d-3f56-4839-aaf0-e8f4167c0f8a
Local pid:
pubs:817446
Language:
English

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