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Human Salmonella Typhi exposure generates differential multifunctional cross-reactive T-cell memory responses against Salmonella Paratyphi and invasive nontyphoidal Salmonella

Abstract:

Objective:
There are no vaccines for most of the major invasive Salmonella strains causing severe infection in humans. We evaluated the specificity of adaptive T memory cell responses generated after Salmonella Typhi exposure in humans against other major invasive Salmonella strains sharing capacity for dissemination.

Methods:
T memory cells from eleven volunteers who underwent controlled oral challenge with wtS. Typhi were characterised by flow cytometry for cross-reacti...

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Publication status:
Published

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Files:
Publisher copy:
10.1002/cti2.1178

Authors


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Name:
Wellcome Trust
Grant:
092661 Milestone
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Name:
Oxford Biomedical Research Centre
Grant:
BZR01462
More from this funder
Name:
National Institute for Health Research
Grant:
NF-SI-0617-10036
Publisher:
Wiley Open Access
Journal:
Clinical & Translational Immunology More from this journal
Volume:
9
Issue:
9
Article number:
e1178
Publication date:
2020-01-01
Acceptance date:
2020-08-17
DOI:
EISSN:
2050-0068
Language:
English
Keywords:
Pubs id:
1136335
Local pid:
pubs:1136335
Deposit date:
2020-10-07

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