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The use of phosphate bioisosteres in medicinal chemistry and chemical biology

Abstract:

Phosphate and pyrophosphate groups play a central role in cellular signalling and consequently are of great interest to both medicinal chemists and chemical biologists. However, the design of molecules that can interfere with phosphate-based processes is recognised as a significant challenge, especially when the resulting compounds must show good cellular penetration and stability. Herein, we have reviewed the full range of phosphate bioisosteres currently reported and provided the context of...

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Publication status:
Published

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Publisher copy:
10.1039/c2md20079a

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
MEDCHEMCOMM More from this journal
Volume:
3
Issue:
7
Pages:
735-751
Publication date:
2012-07-01
DOI:
EISSN:
2040-2511
ISSN:
2040-2503
Pubs id:
pubs:342677
UUID:
uuid:d48692a7-0ab2-4ae3-8a40-9a946df95f09
Local pid:
pubs:342677
Source identifiers:
342677
Deposit date:
2012-12-19

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