Journal article

Nanog fluctuations in embryonic stem cells highlight the problem of measurement in cell biology

Abstract:: A number of important pluripotency regulators, including the transcription factor Nanog, are observed to fluctuate stochastically in individual embryonic stem cells. By transiently priming cells for commitment to different lineages, these fluctuations are thought to be important to the maintenance of, and exit from, pluripotency. However, because temporal changes in intracellular protein abundances cannot be measured directly in live cells, fluctuations are typically assessed using geneticall...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Smith, R., Stumpf, P., Ridden, S., Sim, A., Filippi, S., Harrington, H., & MacArthur, B. (2017). Nanog fluctuations in embryonic stem cells highlight the problem of measurement in cell biology. Biophysical Journal, 112(12), 2641–2652.

MLA Style

Smith, R., et al. “Nanog Fluctuations in Embryonic Stem Cells Highlight the Problem of Measurement in Cell Biology.” Biophysical Journal, vol. 112, no. 12, Biophysical Journal, 2017, pp. 2641–52.

Chicago Style

Smith, R, P Stumpf, S Ridden, A Sim, S Filippi, H Harrington, and B MacArthur. 2017. “Nanog Fluctuations in Embryonic Stem Cells Highlight the Problem of Measurement in Cell Biology.” Biophysical Journal 112 (12): 2641–52.
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Files:: 1-s2.0-S000634951730509X-main.pdf

(Preview, Version of record, pdf, 1.1MB, Terms of use)

Publisher copy:: 10.1016/j.bpj.2017.05.005

Authors

+ Smith, R More by this author

Role:

Author

+ Stumpf, P More by this author

Role:

Author

+ Ridden, S More by this author

Role:

Author

+ Sim, A More by this author

Role:

Author

+ Filippi, S More by this author

Role:

Author

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Funding

+ Biotechnology and Biological Sciences Research Council (BBSRC) More from this funder

Grant:

BB/L000512/1

+ Engineering and Physical Sciences Research Council More from this funder

Grant:

EP/K041096/1

+ Royal Society More from this funder

Funding agency for:

Harrington, H

Bibliographic Details

Publisher:: Biophysical Journal
Journal:: Biophysical Journal More from this journal
Volume:: 112
Issue:: 12
Pages:: 2641-2652
Publication date:: 2017-06-20
Acceptance date:: 2017-05-05
DOI:: 10.1016/j.bpj.2017.05.005
EISSN:: 1542-0086
ISSN:: 0006-3495
Pmid:: 28636920

Item Description

Language:: English
Keywords:: Green Fluorescent Proteins

Microscopy, Fluorescence

Models, Molecular

Kinetics

Gene Knock-In Techniques

Gene Expression

Mice

Genes, Reporter

Male

Animals

Flow Cytometry

Immunohistochemistry

Embryonic Stem Cells

Cell Biology

Gene Expression Regulation

RNA, Messenger

Nanog Homeobox Protein
Pubs id:: pubs:702411
UUID:: uuid:d474ff00-12fc-40d1-a6ae-972133a1f32e
Local pid:: pubs:702411
Source identifiers:: 702411
Deposit date:: 2017-09-01

Terms of use

Copyright holder:: © 2017 Biophysical Society
Copyright date:: 2017
Notes:: This is an open access article under the CC BY license (http://
creativecommons.org/licenses/by/4.0/).

Licence:: CC Attribution (CC BY)

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