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Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes.

Abstract:

The exposure of human T-cell clones to supra-immunogenic concentrations of peptide antigen in the absence of accessory cells induces antigen-specific unresponsiveness. Using this model we have investigated the ability of cytokines to modulate the induction of, or reversal of, T-cell tolerance. Our findings demonstrate that interleukin-2 (IL-2), but not interferon-gamma (IFN-gamma) or interleukin-1 (IL-1), is able to inhibit the induction of T-cell unresponsiveness in a dose-dependent fashion....

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Publication status:
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Immunology
Volume:
64
Issue:
3
Pages:
413-417
Publication date:
1988-07-05
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:d463e45d-10b4-4a10-b947-cc4e6493f60a
Source identifiers:
481786
Local pid:
pubs:481786

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