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Journal article

The transcriptional landscape of αβ T cell differentiation.

Abstract:

The differentiation of αβT cells from thymic precursors is a complex process essential for adaptive immunity. Here we exploited the breadth of expression data sets from the Immunological Genome Project to analyze how the differentiation of thymic precursors gives rise to mature T cell transcriptomes. We found that early T cell commitment was driven by unexpectedly gradual changes. In contrast, transit through the CD4(+)CD8(+) stage involved a global shutdown of housekeeping genes that is rare...

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Publisher copy:
10.1038/ni.2590

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Journal:
Nature immunology
Volume:
14
Issue:
6
Pages:
619-632
Publication date:
2013-06-05
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
URN:
uuid:d46269c8-de5c-4e4c-8903-dc31d5c6d65c
Source identifiers:
426234
Local pid:
pubs:426234

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