Journal article
Foxn1 regulates in postnatal thymic epithelial cells key target genes essential for T cell development
- Abstract:
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Thymic epithelial cell differentiation, growth and function depend on the expression of the transcription factor Foxn1, however its target genes have never been physically identified. Using novel static and inducible genetic model systems and chromatin studies, we provide now a genome wide map of direct Foxn1 target genes for postnatal thymic epithelia and define the Foxn1 binding motif. We detail the function of Foxn1 in these cells and demonstrate that in addition to the t...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, pdf, 25.1MB)
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- Publisher copy:
- 10.1038/ni.3537
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Authors
Funding
+ Swiss National Foundation
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Funding agency for:
Hollander, G
Grant:
105045/Z/14/Z
Medical Research Council
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Immunology Journal website
- Volume:
- 17
- Pages:
- 1206–1215
- Publication date:
- 2016-08-01
- Acceptance date:
- 2016-07-19
- DOI:
- ISSN:
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1529-2916
- Source identifiers:
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634673
Item Description
- Pubs id:
-
pubs:634673
- UUID:
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uuid:d45be9f8-dd30-47af-963f-7c204ddf5fbf
- Local pid:
- pubs:634673
- Deposit date:
- 2016-07-20
Terms of use
- Copyright holder:
- Nature America, Inc
- Copyright date:
- 2016
- Notes:
- © 2016 Nature America, Inc. All rights reserved.
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