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Foxn1 regulates in postnatal thymic epithelial cells key target genes essential for T cell development

Abstract:

Thymic epithelial cell differentiation, growth and function depend on the expression of the transcription factor Foxn1, however its target genes have never been physically identified. Using novel static and inducible genetic model systems and chromatin studies, we provide now a genome wide map of direct Foxn1 target genes for postnatal thymic epithelia and define the Foxn1 binding motif. We detail the function of Foxn1 in these cells and demonstrate that in addition to the t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ni.3537

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
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Funding agency for:
Handel, A
Grant:
100643/Z/12/Z
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Funding agency for:
Hollander, G
Grant:
105045/Z/14/Z
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Funding agency for:
Hollander, G
Grant:
105045/Z/14/Z
Medical Research Council More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Immunology Journal website
Volume:
17
Pages:
1206–1215
Publication date:
2016-08-01
Acceptance date:
2016-07-19
DOI:
ISSN:
1529-2916
Source identifiers:
634673
Pubs id:
pubs:634673
UUID:
uuid:d45be9f8-dd30-47af-963f-7c204ddf5fbf
Local pid:
pubs:634673
Deposit date:
2016-07-20

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