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Foxn1 regulates in postnatal thymic epithelial cells key target genes essential for T cell development

Abstract:

Thymic epithelial cell differentiation, growth and function depend on the expression of the transcription factor Foxn1, however its target genes have never been physically identified. Using novel static and inducible genetic model systems and chromatin studies, we provide now a genome wide map of direct Foxn1 target genes for postnatal thymic epithelia and define the Foxn1 binding motif. We detail the function of Foxn1 in these cells and demonstrate that in addition to the t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ni.3537

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More from this funder
Name:
Swiss National Foundation
Funding agency for:
Hollander, G
Grant:
105045/Z/14/Z
More from this funder
Name:
Wellcome Trust
Funding agency for:
Handel, A
Hollander, G
Grant:
100643/Z/12/Z
105045/Z/14/Z
105045/Z/14/Z
Publisher:
Nature Publishing Group
Journal:
Nature Immunology More from this journal
Volume:
17
Pages:
1206–1215
Publication date:
2016-08-01
Acceptance date:
2016-07-19
DOI:
ISSN:
1529-2916
Pubs id:
pubs:634673
UUID:
uuid:d45be9f8-dd30-47af-963f-7c204ddf5fbf
Local pid:
pubs:634673
Source identifiers:
634673
Deposit date:
2016-07-20

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