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DAncing past the DAT at a DA synapse.

Abstract:

Spillover of dopamine (DA) from a release site into the extrasynaptic space is widely acknowledged. Indeed, spillover is necessary for signalling by DA because its receptors are predominantly extrasynaptic. Dopamine transporters (DATs) are often considered to participate in this process by 'gating' spillover. This article reviews the competition between DATs and diffusion in sculpting extracellular DA transients after quantal release, using a model based on data from the literature. Its concl...

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Publication status:
Published

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Publisher copy:
10.1016/j.tins.2004.03.011

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Trends in neurosciences
Volume:
27
Issue:
5
Pages:
270-277
Publication date:
2004-05-05
DOI:
EISSN:
1878-108X
ISSN:
0166-2236
URN:
uuid:d452cd14-53d9-4ef7-9dff-869c2a3d3564
Source identifiers:
113941
Local pid:
pubs:113941

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